An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Xu, S. et al. Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03054-y (2026). Source: Read Full Article

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A bridge recombinase for human genome editing

Bridge RNA-guided recombinases, which originate from the IS110 family of bacterial insertion sequence elements, show promise as programmable systems for genome editing. However, most work so far has been done in bacteria. Writing in Science, Pelea et al. provide insights into a bridge recombinase that can edit human cells. Bridge recombinases act as editors by…

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