Quantifying endosomal escape in vivo to guide lipid nanoparticle design

Quantifying endosomal escape in vivo to guide lipid nanoparticle design Fig. 1: Workflow for in vivo quantification of LNPs from endosomal escape.

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03047-x

A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery.


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Sam Miller

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