Deeper is not always better in plasma proteomics

Deeper is not always better in plasma proteomics Fig. 1: Depth versus contamination across plasma workflows and an MS-based ‘iceberg’.

Nature Biotechnology, Published online: 22 April 2026; doi:10.1038/s41587-026-03106-3

This Comment discusses depth, robustness and bias in plasma proteomics, concluding that increasing the depth of coverage does not necessarily translate to quantitative robustness.


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Sam Miller

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