First-in-Class Vepdegestrant Approved in Advanced Breast Cancer

First-in-Class Vepdegestrant Approved in Advanced Breast Cancer

The FDA approved oral vepdegestrant (Veppanu) for adults with advanced or metastatic estrogen receptor (ER)-positive/HER2-negative breast cancer, the agency announced on Friday. Approval of the first-in-class proteolysis targeting chimera (PROTAC) — a type of heterobifunctional protein degrader therapy — stipulates use in patients with ESR1-mutated disease that has progressed following at least one line of…

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Novel ICD Lead for Conduction System Pacing Enters the Arena

Novel ICD Lead for Conduction System Pacing Enters the Arena

A dedicated bipolar implantable cardioverter-defibrillator (ICD) lead for conduction system pacing (CSP) performed well in a first-in-human multicenter study. Placement of the novel UltiSynq CSP ICD lead, designed for left bundle branch area (LBBA) pacing, met expectations for safety and effectiveness in over 200 patients with indications for novo ICD or cardiac resynchronization therapy defibrillator…

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You're About to See Less Slop on Instagram

You’re About to See Less Slop on Instagram

Instagram ain’t what it used to be. What started as a simple platform to share retro-inspired photos with friends and family quickly turned into a social media mega-app. You can still share photos, sure, but the platform now offers just about everything, from livestreams to short-form video feeds. In fact, for some users, the Instagram…

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The expert on 'super aging' breaks down the science — and grift — in anti-aging : NPR

The expert on ‘super aging’ breaks down the science — and grift — in anti-aging : NPR

Cardiologist Eric Topol says resistance training, not just exercise, is key to longevity. Capuski/Getty Images hide caption toggle caption Capuski/Getty Images It’s a strange moment for growing old. Longevity is a cultural obsession: Biohackers plunge into ice baths, influencers push peptides, and tech elites pour ungodly sums into chasing immortality. Medical breakthroughs using AI promise…

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New Therapies for Chronic Spontaneous Urticaria Expand Options Beyond Anti-IgE Care

New Therapies for Chronic Spontaneous Urticaria Expand Options Beyond Anti-IgE Care

Discussions at the American Academy of Dermatology annual meeting highlighted a rapidly evolving treatment landscape for chronic spontaneous urticaria (CSU), with new targeted therapies expanding options beyond traditional antihistamines and anti-immunoglobulin E (IgE) approaches. In this exclusive MedPage Today video, Gil Yosipovitch, MD, of the University of Miami Miller School of Medicine, reflects on the…

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