New TYK2 Inhibitors for Psoriasis Achieve High Clearance Rates in Randomized Trials

New TYK2 Inhibitors for Psoriasis Achieve High Clearance Rates in Randomized Trials

DENVER — Two drug candidates to expand oral therapy options for psoriasis had similar and consistent performances in separate phase III clinical trials reported here. The allosteric TYK2 inhibitor zasocitinib achieved at least 75% improvement in the psoriasis area and severity index (PASI 75) and physician-rated clear or almost clear skin (physician global assessment [PGA]…

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ChatGPT Flops for Psychotic Prompts; ADHD Drug and Psychosis; Metabolic Psychiatry

ChatGPT Flops for Psychotic Prompts; ADHD Drug and Psychosis; Metabolic Psychiatry

Three different versions of ChatGPT showed high rates of inappropriate or partially appropriate responses to psychotic prompts, with the free version performing the worst. (JAMA Psychiatry) Social media doesn’t need to be so addictive for teens, and researchers have some ideas. (NPR) A cohort study from Denmark and Sweden raised concerns about severe relapses after…

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