Biotechnology Archives

Science

Unpaired data as a first-order challenge in single-cell and spatial proteomics

Sam Miller22 hours ago02 mins

Genentech, South San Francisco, CA, USA Mikaela Koutrouli, Carolina Leote, Christopher M. Rose & John C. Marioni Department of Molecular Biology and Digital Science Center (DiSC), University of Innsbruck, Innsbruck, Austria Francesca Finotello & Felix Petschko Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark Erwin M. Schoof, Pedro Aragon-Fernandez & Valdemaras Petrosius Center for Disease Neurogenomics, Icahn School of Medicine…

FDA flags misleading claims for cancer drug by biotech billionaire Patrick Soon-Shiong

Sam Miller3 days ago03 mins

WASHINGTON — Federal health officials issued a warning Tuesday over misleading statements made by biotech billionaire Dr. Patrick Soon-Shiong, who recently told podcast listeners that his company’s bladder cancer drug may be able to treat, cure or even prevent other types of cancers. The warning letter from the Food and Drug Administration takes issue with…

‘Zombie’ cells created by transplanting genomes into dead bacteria

Sam Miller5 days ago05 mins

Colonies of bacterial cells under a microscope. The blue colony is expressing the synthetic genome; the white colonies are Mycoplasma capricolum cells that survived the mitomycin C treatment Nacyra Assad-Garcia A living, synthetic cell has been made by transplanting a complete genome into a dead bacterium, bringing it back to life. The breakthrough could help…

An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

Sam Miller1 week ago01 mins

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Xu, S. et al. Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03054-y (2026). Source: Read Full Article

Science

A bridge recombinase for human genome editing

Sam Miller2 weeks ago01 mins

Bridge RNA-guided recombinases, which originate from the IS110 family of bacterial insertion sequence elements, show promise as programmable systems for genome editing. However, most work so far has been done in bacteria. Writing in Science, Pelea et al. provide insights into a bridge recombinase that can edit human cells. Bridge recombinases act as editors by…

Quantifying endosomal escape in vivo to guide lipid nanoparticle design

Sam Miller2 weeks ago01 mins

Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03047-x A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery. Source: Read Full Article

B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers?

Sam Miller2 weeks ago01 mins

Nature Biotechnology, Published online: 10 March 2026; doi:10.1038/s41587-026-03069-5 Deep B cell depletion is delivering transformative clinical results in autoimmune diseases. Dealmakers are wagering on the best tools for the job. Source: Read Full Article

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Prince Andrew’s Epstein Scandal Planned by MI5

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Iconic global landmarks turn off lights

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Biotechnology

Unpaired data as a first-order challenge in single-cell and spatial proteomics

FDA flags misleading claims for cancer drug by biotech billionaire Patrick Soon-Shiong

‘Zombie’ cells created by transplanting genomes into dead bacteria

An engineered E. coli strain sustains intratumoral nitric oxide production to boost effectiveness of tumor immunotherapy

A bridge recombinase for human genome editing

Quantifying endosomal escape in vivo to guide lipid nanoparticle design

B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers?