Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Zhao, X. et al. A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03057-9 (2026). Source: Read Full Article
Genentech, South San Francisco, CA, USA Mikaela Koutrouli, Carolina Leote, Christopher M. Rose & John C. Marioni Department of Molecular Biology and Digital Science Center (DiSC), University of Innsbruck, Innsbruck, Austria Francesca Finotello & Felix Petschko Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark Erwin M. Schoof, Pedro Aragon-Fernandez & Valdemaras Petrosius Center for Disease Neurogenomics, Icahn School of Medicine…
Scientists have extracted and analyzed DNA from 216 canid remains, including 181 from Paleolithic and Mesolithic Europe. The oldest data that they recovered are from a 14,200-year-old dog from the Kesslerloch site in Switzerland. Their results suggest that domesticated dogs (Canis lupus familiaris) predate farming and share deep ancestry with wolves (Canis lupus) from Eurasia,…
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This is a summary of: Xu, S. et al. Sustained nitric oxide production by engineered E. coli remodels the tumor microenvironment and potentiates immunotherapy. Nat. Biotechnol. https://doi.org/10.1038/s41587-026-03054-y (2026). Source: Read Full Article
Bridge RNA-guided recombinases, which originate from the IS110 family of bacterial insertion sequence elements, show promise as programmable systems for genome editing. However, most work so far has been done in bacteria. Writing in Science, Pelea et al. provide insights into a bridge recombinase that can edit human cells. Bridge recombinases act as editors by…
Nature Biotechnology, Published online: 11 March 2026; doi:10.1038/s41587-026-03047-x A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery. Source: Read Full Article
Nature Biotechnology, Published online: 10 March 2026; doi:10.1038/s41587-026-03069-5 Deep B cell depletion is delivering transformative clinical results in autoimmune diseases. Dealmakers are wagering on the best tools for the job. Source: Read Full Article
