Complement Inhibitor Slowed Kidney Decline in IgA Nephropathy

Complement Inhibitor Slowed Kidney Decline in IgA Nephropathy

Iptacopan significantly slowed kidney function decline over 24 months compared with placebo in adults with IgA nephropathy. The complement inhibitor was granted accelerated approved in 2024; continued approval was contingent on demonstrating slowed kidney decline. Fewer participants in the iptacopan group reached the composite kidney-failure endpoint. Iptacopan (Fabhalta) slowed kidney function decline in adults with…

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Garlic recalled because of botulism risk

Garlic recalled because of botulism risk

According to press reports, the Food and Drug Administration has issued its most serious recall for peeled garlic sold in New York, Vermont and Pennsylvania over a potential botulism risk. The Class I recall is for Christopher Ranch Garlic, sold in 6-ounce containers at Tops stores in those states, according to a March 27 announcement…

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Your Weekly Horoscope: March 29–April 4, 2026

Your weekly horoscope is here. The cosmic love language shifts on Monday as Venus, the pleasure principle, heads up the earthy sign of Taurus. While we are in the fast and furious Aries season, this shift may contribute in areas of diplomacy. In ancient astrological thinking, Venus always wins. She pacifies that mad Mars-y principle….

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We Have a Substance Use Prevention Problem

We Have a Substance Use Prevention Problem

Every week in the pediatric emergency department, I watch the consequences of adolescent substance use arrive through our doors. Overdoses. Acute intoxication. Psychiatric crises triggered by substances that started as experimentation years earlier. And almost every time, somewhere in the history, there is a moment when prevention could have worked — and didn’t. We have…

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